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The US has formally recognized Syria's opposition rebel coalition as the "legitimate representative" of the people, says President Barack Obama.
Speaking to ABC News, Mr Obama said the coalition was now inclusive, reflective and representative enough for the US to take this "big step," BBC reported.
The UK, France, Turkey and Gulf states had already given their recognition.
Activists say some 40,000 people have died in more than 18 months of battle against President Bashar al-Assad.
More than half a million people have now fled the conflict in Syria to neighbouring countries, according to the UN's refugee agency.
Mr Obama said the emerging coalition had earned the right to represent the Syrian people, but issued a note of caution as well.
"Obviously, with that recognition comes responsibilities," Mr Obama said.
"To make sure that they organize themselves effectively, that they are representative of all the parties, [and] that they commit themselves to a political transition that respects women's rights and minority rights."
Mr Obama's announcement comes as foreign ministers from 70 countries are preparing to meet in Morocco on Wednesday to discuss the situation in Syria.
The Marrakech meeting will be the first time that the Friends of Syria conference is attended by the Syrian National Coalition.
US recognition of the coalition does not mean the US will begin arming rebel groups, but officials told ABC that might be approved if it was thought to help achieve a political solution in Syria.
Mr Obama warned that the US would not support extremist elements within the opposition coalition.
"Not everybody who's participating on the ground in fighting Assad are people who we are comfortable with," he said.
"There are some who, I think, have adopted an extremist agenda, an anti-US agenda, and we are going to make clear to distinguish between those elements."