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One person has been killed and three others wounded in a shooting on the campus of Seattle Pacific University, the BBC reported.
Hospital officials said the person killed was a man in his 20s. A woman is also in a very serious condition with a gunshot wound to her upper body.
Police in the Washington state city said a man, 26, had been arrested, and was believed to have been acting alone.
A student disarmed the gunman and several other students held him until police arrived, officers said.
At a press conference, Assistant Chief Paul McDonagh said the actions of this student, and the others who came to his aid, prevented a more serious tragedy.
The other two injuries were sustained by men in their 20s. One is in a stable condition and the other has minor wounds to the abdomen.
In a statement, Seattle Mayor Ed Murray referred to previous fatal shootings in the city and added: "Once again the epidemic of gun violence has come to Seattle, the epidemic of gun violence that is haunting this nation."