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Pope Leo XIV appealed for "no more war" in a message to world powers during his first Sunday address at the Vatican, BBC News reported.
Reflecting on current conflicts, the newly selected pontiff called for a "lasting peace" in the war in Ukraine, a ceasefire in Gaza, and welcomed Saturday's agreement to end recent hostilities between India and Pakistan.
He said he was "deeply hurt" by events in Gaza, expressed hope for a "lasting accord" between India and Pakistan, and wished for a "authentic, true and lasting peace" in Ukraine.
The Pope also recited the Regina Caeli prayer, in honour of the Virgin Mary, to the crowd in St Peter's Square.
Pope Leo was chosen as the new leader of the Catholic Church on Thursday following the death of his predecessor, Pope Francis, and a two-day conclave in Vatican City.
On Saturday, he visited a shrine outside Rome before praying at Francis' tomb inside the basilica of Santa Maria Maggiore.
Pope Leo will be formally inaugurated at a Mass in St Peter's Square next week on 18 May.
Three years ago, as Bishop Robert Prevost, he denounced Russia's full-scale invasion of Ukraine as an imperialist war and condemned crimes against humanity he said were being committed there.
On Sunday, he restricted himself to echoing his predecessor, Francis, in calling for peace.
"I would also like to address the powerful people of the world, repeating the always current call: 'no more war'," he told the crowd from the central balcony of St Peter's Basilica.
"The immense tragedy of the Second World War ended 80 years ago...now we're facing the tragedy of a third world war in pieces."
The pontiff continued: "I carry in my heart the suffering of the beloved Ukrainian people.
"May whatever is possible be done to reach an authentic, true and lasting peace as quickly as possible. May all the prisoners be freed. May children return to their families.
"And I am deeply hurt by what is happening in the Gaza Strip.
"May a ceasefire immediately come into effect. May humanitarian aid be allowed into the civilian population and may all hostages be freed."
He added: "I was happy to hear on the other hand that there was a ceasefire between India and Pakistan, and I hope that through the coming negotiations we might soon come to a lasting accord."